Wyeth, Elan and Bapineuzumab -- How to Lie With (Drug) Statistics

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  georgejjl09/08/08 Report as spam
  1

  RE: Wyeth, Elan and Bapineuzumab -- How to Lie With (Drug) Statistics

  Look at page 15 at a dose of 0.15 mg/kg for APOE4 carriers and page 17 at a dose of 0.5 mg/kg for APOE4 noncarriers.
  
  http://library.corporate-ir.net/library/88/883/88326/items/302302/ELNWYE20080729.pdf
  
  Those a trualy amazing numbers.
  
  How do you explain those numbers?
  
  Did you know that most Alzheimer's drugs exhibit an inverterted "U" shaped dose response?
  
  What did Dr. Sid Gilman MD, Distinguished University Professor of Neurology at the University of Michigan, have to say about bapineuzumab?
  
  
  Good luck and God bless,
  
  George Lucas

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  georgejjl09/08/08 Report as spam
  2

  RE: Wyeth, Elan and Bapineuzumab -- How to Lie With (Drug) Statistics

  http://library.corporate-ir.net/library/88/883/88326/items/302302/ELNWYE20080729.pdf

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  georgejjl09/09/08 Report as spam
  3

  RE: Wyeth, Elan and Bapineuzumab -- How to Lie With (Drug) Statistics

  http://library.corporate-ir.net/library/88/883/88326/items/302302/ELNWYE20080729.pdf
  
  Why won't this accpet the link as posted.

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  zdnetregistration11/06/09 Report as spam
  4

  RE: Wyeth, Elan and Bapineuzumab -- How to Lie With (Drug) Statistics

  Analyses post-hoc after the fact are commonplace in medical statistics. So common in fact, that the FDA carefully reviews all relevant subgroups to see if efficacy differs in one subgroup vs another. This is even a required part of an NDA application.
  
  Post-hoc looks at subgroups are by themselves not convincing for efficacy, but still are useful for generating hypotheses for future studies.
  
  This is by no means a fabricated "Lie with (drug) statistics". So do everyone a favor and pick up a good book on statistics and read it. You might learn something or two.