Question-and-Answer Session
Operator
[Operator Instructions]. The first question is from Eun Yang with Jefferies.
Eun Yang
Hi, thanks. I have a couple of questions on the diabetes program. First, Biodel has a similar product, the new drug delivery over insulin and clinical development and they are coming out with a Phase I data towards the end of this year. And, could you help us understand the advantages that you may have, your program may have over Biodel?
Jonathan Lim
Sure. So, we both have Sub-Q formulations of different insulins, the power of PEG PH20 technology is the fact it can interface with either of the proprietary insulins better on the marketplace in terms of any one of the three analog insulins that are used for meal-time administration, the other thing is that we are able to co-formulated it with the regular insulin products, and as you can see we have a differentiated profile on both the PK and the PD dimensions for actually all of those products. We have ready to use formulation. So, we’re targeting basically a very simple to use administration via a pen type of system and also will be seeking to directly compare the performance characteristics of our product versus the best in class products that are on the market today.
Eun Yang
They all show that the, not just the Humulin but they also show insulin analogs are using there drug delivery system, they were able to achieve a better insulin of absorption. So, far based on the Phase I data you have seen with PH20 and Biodel’s data, is there any, is it hard to differentiate how those two products are working differently or similarly?
Jonathan Lim
Well, I’ll speak to the performance characteristics of our product and basically if you look at both the impact on the T-max or the time to maximal concentration and if you also look at the C-max or the maximal concentration itself the combination of PH20 with regular insulin and the combination of PH20 with basically the analog product you will see that there is a profound increase in the C-max for both products, both Halo products and there is also a profound decrease in T-max for both products. And, the overall area under the curve is increase where you wanted to increase which is the early time points. But, it also has significantly decreased where you wanted to decrease which is later on in the insulin absorption Phase to avoid the hypoglycemic events. So, for the same dose of insulin given with PH20, we believe that the T-max and the C-max from a pharmacokinetic profile are really compelling. And so, if you really want to do a true apples-to-apples types of comparison with similar doses I’d encourage looking at the T-max the C-max that area under the curve and just seeing what you can see there.
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