Question-and-Answer Session
Operator
(Operator instructions) Your first question comes from the line of Andrew Finkelstein with Leerink Swann.
Andrew Finkelstein - Leerink Swann
I was hoping you could give some additional color on AMITIZA in terms of the amount of stocking seen for the 8 mcg in the second quarter as well as on the promotional front, when you might consider starting DTC with Takeda and any differences in the formulary position between the two strengths?
Brad E. Fackler
First of all, the stocking program went quite well in that we stocked slightly over what our goal was, and so at the time of launch it was available in approximately 65% of the retail outlets around the country. DTC is ongoing now. There is a web-based program that is out there and that is essentially since the DDW meeting there has been a callout in the amitiza.com website and other associated websites that announced the approval of the 8 mcg strength. Beginning very shortly, we will also enhance that and it will include a lead generation within the website as well as connections from key search engines such as Yahoo and Google. In addition, we will be kicking off in-physician office patient education programs as well as some in-pharmacy compliance programs, and as I said those will be kicking off very shortly.
Formulary, we continue to enjoy high levels of availability through managed care plans. We generally are at tier 2 or tier 3 coverage. We have unrestricted access in about 90% of the covered lives. In general, most of the plans have considered the 8 mcg as a line extension, so there are no additional hurdles that have been placed on that, and the copays have remained fairly constant in the mid $30 range. As I said in my comments, we are detecting that these plans are seen to be, and I should say, seen to be because we are still researching this at this point, but they seem to be facilitating the use of the OTC which obviously would result in no cash outlay for the plan. So we are working with Takeda right now to address pull-through and other strategies that can help us pull this through the channels.
Operator
Your next question comes from the line of Ian Sanderson with Cowen and Company.
Ian Sanderson – Cowen and Company
Actually a followup on the AMITIZA stocking numbers, could you just maybe give us the net impact? You had trade inventory of, I think it was estimated that you booked royalty revenues of $1.9 million related to the inventory stocking in Q2, and then there was the $800,000 delayed shipments from Q1, so maybe give us an idea of what the net royalty revenue impact from those was in Q2, and then secondly on the R&D spending side, the numbers seem relatively high for the quarter, and just what we should be a reasonable run rate to expect for the balance of the year?
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